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pentobarbital will lessen the extent or effect of efavirenz by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.pentobarbital improves effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Caution/Observe. Coadministration of ifosfamide with CYP2B6 inducers could raise metabolism of ifos